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There is no cure, they dont know the cause. I have had it for over 20 years. Mirapex,a drug for Parkinsons is very effective in treating the symptoms,. most narcotics will also give temporary relief, I recently was in ICU with Congestive Heart failure the end result of being dangerously low on iron. After tending to the obvious the search started for the cause of other symptoms I was having. One Dr laughed at dangerously close to describing the lack of iron. He said it was more accurate to say I didnt have any iron. The culpert for a whole host of problems was Hep C that I had from a contaminated blood transfusion. I had a iron infusion and that took care of the RLS and chronic insomnia. That was the last day of RLS. Dont know if it is permanently taken care of or if it would come back